Cooling Agent WS-12 Powder

Cooling Agent WS-12 Powder

What is Cooling Agent WS-12?

TIZAN Cooling Agent WS-12 powder is a potent TRPM8 agonist that acts as a cooling agent (EC50 = 193 nM). It robustly activated TRPM8 in low micromolar concentrations (EC50 12+/-5 microM) thereby displaying a higher potency and efficacy compared to menthol (EC50 196+/-22 microM). The selectivity profile of WS-12, its several-fold higher potency and around two-fold increase in efficacy compared to menthol warrants its potential utility for therapy in chronic neuropathic pain states and as a diagnostic probe in prostate cancer.

It is a menthol derivative. But unlike menthol, it is virtually nonvolatile, odorless and tasteless. It offers one of the strongest initial cooling impacts and a significantly longer lasting effect comparing with such conventional coolants such as WS-3, WS-5, and WS-23. It has potential for use in mint flavors in oral care applications as well as confectionary and chewing gum depending on dosage levels. In addition it can be used at low levels to impart freshness into berry, citrus and other fruit flavors in a variety of applications. WS-12 has been found to cool primarily at the front of the tongue.

Cooling Agent WS-12 Chemical & Physical Properties

Chemical NameCyclohexanecarboxamide, N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-, (1R, 2S, 5R)-
AppearanceWhite Fine Powder
OdorMild cooling, slight menthol odor, almost odorless.
CAS No.68489-09-8
FEMA No.4681
Molecular Weight289.416
Melting Point177℃ – 181℃
CategoryFlavoring Agents/Cooling Agent

Cooling Agent WS-12 Application

  1. Applied in daily flavor.
  2. Applied in food flavor.
  3. Applied in industrial flavor.
  4. Applied in tobacco flavor.

Best Cooling Agent WS-12 Powder

TIZAN enjoys long term relationships with our clients because we focus on customer service and providing great products. If you are interested in Cooling Agent WS-12, we are flexible with the customization of orders to suit your specific need and our quick lead time on orders guarantees you’ll have great tasting our product on-time. Cooling Agent WS-12 is our specialty.

We also focus on value-added services. We are available for service questions and information to support your business.

Why Choose TIZAN Cooling Agent WS-12 Powder?

TIZAN has been a major supplier of the cooling compounds including WS-3, WS-5, WS-12, WS-23 and Menthyl Lactate. These products allow our customers to use coolants in a broader array of market segments and applications. Tizan research demonstrates individual coolants are perceived in specific areas of the mouth with different cooling profiles. Each coolant provides unique characteristics in terms of cooling intensity and longevity, combined with negligible odor and low volatility.

TIZAN specialize in Cooling Agent WS-12 for several years, we supply product with competitive price, and our product is of the highest quality and undergoes strict, independent testing to ensure that it is safe for consumption around the world.

Where to buy Cooling Agent WS-12 Powder?

Just send email to [email protected], or submit your requirement in bottom form, we are of service at any time


WS-12 Powder is light sensitive, the solid material and any solutions obtained are protected from exposure to light.

  • 25Kg/Fiber Drum, double plastic bag inside, with carton outside.
  • Sample – aluminum foil bag vacuum packing.

Related products

Scroll to Top