What is cooling agent WS-12 powder?

Cooling agent WS-12 powder is a potent TRPM8 agonist that acts as a cooling agent (EC50 = 193 nM). It robustly activated TRPM8 in low micromolar concentrations (EC50 12+/-5 microM), thereby displaying a higher potency and efficacy than menthol (EC50 196+/-22 microM). The selectivity profile of WS-12, its several-fold higher potency, and around two-fold increase in efficacy compared to menthol warrants its potential utility for therapy in chronic neuropathic pain states and as a diagnostic probe in prostate cancer.

It is a menthol derivative. But unlike menthol, it is virtually nonvolatile, odorless, and tasteless. It offers one of the strongest initial cooling impacts and a significantly longer-lasting effect than conventional coolants such as WS-3WS-5, and WS-23. It has the potential for use in mint flavors in oral care applications and confectionery and chewing gum, depending on dosage levels. Besides, it can be used at low levels to impart freshness into the berry, citrus, and other fruit flavors in various applications. WS-12 has been found to cool primarily at the front of the tongue.

Cooling agent WS-12 powder chemical & physical properties

Chemical NameCyclohexanecarboxamide, N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-, (1R, 2S, 5R)-
AppearanceWhite Fine Powder
OdorMild cooling, slight menthol odor, almost odorless.
CAS No.68489-09-8
FEMA No.4681
Molecular Weight289.416
Melting Point177℃ – 181℃
CategoryFlavoring Agents/Cooling Agent

Cooling agent WS-12 powder is light sensitive, the solid material and any solutions obtained are protected from exposure to light.

  • 25Kg/Fiber Drum, double plastic bag inside, with carton outside.
  • Sample – aluminum foil bag vacuum packing.


  • Daily chemical flavoring agent.
  • Food flavoring agent.
  • Industrial flavoring agent.
  • Tobacco flavoring agent.

Why Choose TIZAN cooling agent WS-12 powder?

We have been a major supplier of cooling compounds, including WS-3WS-5, WS-12, WS-23, and Menthyl Lactate. These products allow our customers to use coolants in a broader array of market segments and applications. Our research demonstrates individual coolants are perceived in specific areas of the mouth with different cooling profiles. Each coolant provides unique characteristics in terms of cooling intensity and longevity, combined with the negligible odor and low volatility.

Where to buy cooling agent WS-12 powder?

Just send an email to [email protected], or submit your requirement in bottom form. We are of service at any time.