What is cooling agent WS-5 powder?

Cooling agent WS-5 powder [Ethyl 3-(p-menthane-3-carboxamide)acetate], CAS No. 68489-14-5, FEMA 4309. It is the latest in a long line of cooling agents. Each has its different ways of cooling different areas of the mouth and tongue and to different degrees. It is one of the strongest of all the cooling agents and is derived from menthol, although it is virtually odorless and has no taste. It provides a smooth and well-rounded cooling effect and primarily affects the roof of the mouth and the back of the tongue.

The neoisomers of WS-5 and menthyl lactate showed higher cooling potency over the l-isomers. Where the neoisomer did not show higher cooling potency, such as WS-3, blending of the two isomers may still be advantageous in providing a better in-use experience, such as was demonstrated with the G-180 neo-G-180 blend, wherein the neoisomer modulated the negative sensory effects from using G-180 alone. The neo-derivatives of menthyl lactate showed surprising cooling power. In particular, neo-menthyl lactate (2S) and neo-menthyl lactate acetate [(1S,2S,5R)-2-isopropyl-5-methyl cyclohexyl-2(S)-acetoxypropanoate] provided very strong initial cooling as well as over the 60 minutes, compared to l-menthyl lactate.

Cooling agent WS-5 powder chemical & physical properties

CAS No.68489-14-5
Density1.0±0.1 g/cm3
Boiling Point390.9±11.0 °C at 760 mmHg
Molecular FormulaC15H27NO3
Molecular Weight269.380
Flash Point190.2±19.3 °C
Exact Mass269.199097
Vapour Pressure0.0±0.9 mmHg at 25°C
Index of Refraction1.462

WS-5 Powder is light sensitive, the solid material and any solutions obtained are protected from exposure to light.

  • 25Kg/Fiber Drum, double plastic bag inside, with carton outside.
  • Sample – aluminum foil bag vacuum packing.


  1. Daily chemical flavoring agent.
  2. Food flavoring agent.
  3. Industrial flavoring agent.
  4. Tobacco flavoring agent.

Where to buy cooling agent WS-5 powder?

Just send an email to [email protected], or submit your requirement in bottom form. We are of service at any time!