What is Levodopa powder (L-DOPA)?
Levodopa powder (L-DOPA) | L-3,4-dihydroxyphenylalanine is an amino acid made and used as part of the normal biology of humans, as well as some animals and plants. Humans and a portion of the other animals that utilize L-DOPA in their biology make it via biosynthesis from the amino acid L-tyrosine. It is the precursor to the neurotransmitters dopamine, norepinephrine, and epinephrine, collectively known as catecholamines.
Furthermore, Levodopa itself mediates neurotrophic factor release by the brain and CNS. It can be manufactured and, in its pure form, is sold as a psychoactive drug with the INN levodopa; trade names include Sinemet, Pharmacopa, Atamet, Stalevo, Madopar, and Prop. As a drug, doctors use it in the clinical treatment of Parkinson’s disease and dopamine-responsive dystonia.
It has a counterpart with opposite chirality, D-DOPA. As is true for many molecules, the human body produces only one of these isomers. The enantiomeric purity of L-DOPA may be analyzed by determination of the optical rotation or by chiral thin-layer chromatography.
Levodopa powder (L-DOPA) benefits
It can replace dopamine lost in Parkinson’s disease because dopamine cannot cross the blood-brain barrier where its precursor can. However, L-DOPA is converted to dopamine in the periphery as well as in the CNS, so it is administered with a peripheral dopamine decarboxylase inhibitor, without which 90% is metabolized in the gut wall and with a COMT inhibitor if possible; this prevents about a 5% loss. Therefore, the form given therapeutically is a prodrug that avoids decarboxylation in the stomach and periphery, can cross the blood-brain barrier, and once in the brain, is converted to the neurotransmitter dopamine by the enzyme aromatic-L-amino-acid decarboxylase.
Specifications
| Item | Specification |
| L-dopa (dry basis C9H11NO4) | 99.00~101.00% |
| Appearance | White to Off-White Powder |
| Solubility | Slightly soluble in water, practically insoluble in ethanol (96%), freely soluble in 1M Hydrochloric Acid and sparingly soluble in 0.1M Hydrochloric Acid. |
| PH Value | 4.5~7.0 |
| Optical Rotation | -1.27°~ -1.34° |
| Absorbance | 137.0 ~ 147.0 |
Shelf Life
2 Years
Storage
Store in tightly sealed containers then places in a cool and dry place while away from moisture, light, and oxygen.
Packing
- Packed in paper-drums and two plastic-bags inside. N.W:25kgs .I.D.35×H51cm.
- 1Kg/Bag (aluminum foil bag).
- Sample: double sealed water plastic bags inside with the aluminum bag outside.
Where to buy Levodopa powder (L-DOPA) | L-3,4-dihydroxyphenylalanine?
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